UPB · NASDAQ
Upstream Bio (UPB) Stock Price & Fundamentals
Upstream Bio (UPB) closed at $770.91 on Oct 9, 2026, up 0.17% from the previous close of $769.62.
Share price, past year
1Y −11.47%Monthly closing prices
| Date | Close |
|---|---|
| Oct 9, 2026 | $770.91 |
| Sep 30, 2026 | $748.94 |
| Aug 31, 2026 | $730.85 |
| Jul 31, 2026 | $751.43 |
| Jun 30, 2026 | $782.79 |
| May 29, 2026 | $806.66 |
| Apr 30, 2026 | $822.23 |
| Mar 31, 2026 | $815.77 |
| Feb 27, 2026 | $802.35 |
| Jan 30, 2026 | $841.85 |
| Dec 31, 2025 | $841.31 |
| Nov 28, 2025 | $777.34 |
| Oct 31, 2025 | $809.28 |
Key statistics
- Market cap
- $42.22B
- P/E (TTM)
- —
- EPS (TTM)
- −$2.89
- Revenue (TTM)
- $3.16M
- Net income (TTM)
- −$156.50M
- Shares outstanding
- 54.8M
- Dividend yield
- —
- 52-week range
- $715.21 – $871.38
Upstream Bio's market cap is $42.22B, based on a share price of $770.91 and 54.8M shares outstanding as of Jun 30, 2026.
Financials
Upstream Bio reported revenue of $2.85M for fiscal 2025, up 20.42% from fiscal 2024.
Upstream Bio reported a net loss of $143.44M in fiscal 2025.
Annual revenue
| Fiscal year | Revenue | Growth | Net income | Net margin | EPS (diluted) | Free cash flow |
|---|---|---|---|---|---|---|
| FY2025ended Dec 31, 2025 | $2.85M | +20.4% | −$143.44M | −5,026.0% | −$2.66 | −$133.44M |
| FY2024ended Dec 31, 2024 | $2.37M | −0.4% | −$62.81M | −2,650.0% | −$5.58 | −$59.68M |
| FY2023ended Dec 31, 2023 | $2.38M | — | −$20.54M | −862.9% | −$12.95 | −$38.07M |
| Quarter | Revenue | Net income | EPS (diluted) |
|---|---|---|---|
| Q2 FY2026ended Jun 30, 2026 | $773.00K | −$39.70M | −$0.73 |
| Q1 FY2026ended Mar 31, 2026 | $1.03M | −$40.59M | −$0.75 |
| Q4 FY2025ended Dec 31, 2025 | $668.00K | −$42.46M | −$0.78 |
| Q3 FY2025ended Sep 30, 2025 | $683.00K | −$33.75M | −$0.63 |
| Q2 FY2025ended Jun 30, 2025 | $937.00K | −$39.97M | −$0.74 |
| Q1 FY2025ended Mar 31, 2025 | $566.00K | −$27.27M | −$0.51 |
| Q4 FY2024ended Dec 31, 2024 | $613.00K | −$21.24M | $12.56 |
| Q3 FY2024ended Sep 30, 2024 | $607.00K | −$15.99M | −$6.96 |
Company profile
- Name
- Upstream Bio, Inc.
- Ticker
- UPB
- Exchange
- NASDAQ
- Industry (SEC SIC)
- Pharmaceutical Preparations
- Headquarters
- 890 Winter Street, Suite 200, Waltham, MA 02451
- Incorporated in
- DE
- Fiscal year ends
- December
- SEC CIK
- 0002022626
Recent SEC filings
- Sep 1, 2026
- Aug 11, 2026
- Aug 11, 2026
- Jun 10, 2026
- May 13, 2026
- May 13, 2026
- Mar 26, 2026
- Mar 26, 2026
Frequently asked questions
What is Upstream Bio's stock price?
Upstream Bio (UPB) closed at $770.91 on Oct 9, 2026, up 0.17% from the previous close of $769.62.
What is Upstream Bio's market cap?
Upstream Bio's market cap is $42.22B, based on a share price of $770.91 and 54.8M shares outstanding as of Jun 30, 2026.
How much revenue does Upstream Bio make?
Upstream Bio reported revenue of $2.85M for fiscal 2025, up 20.42% from fiscal 2024.
Does Upstream Bio pay a dividend?
Upstream Bio's recent filings report no dividends declared over the last four quarters.
Sources and methodology
Fundamentals come from Upstream Bio, Inc.'s filings with the SEC (EDGAR XBRL company facts). Fourth-quarter figures that companies don't report separately are calculated as the fiscal year minus the first three quarters. Trailing twelve-month (TTM) figures sum the latest four quarters. Prices are generated sample data for development. Last updated Oct 9, 2026. Data sources and disclosures